The Ultimate Guide To https://www.ceesdekker.net
The Ultimate Guide To https://www.ceesdekker.net
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Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research pursuits incorporate:
You frequently get entangled in conversations about science and faith. You have also published a number of guides on the subject. Don’t you believe eventually we will know anything and that God’s function are going to be above?
Multicolor imaging from the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Given that 2000, Dekker has shifted the most crucial target of his get the job done towards biophysics in which he experiments the properties of solitary biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, in addition to through the prolonged-time period perspective a large number of attention-grabbing discoveries can be anticipated In this particular subject.[five] Latest lines of analysis in his biophysics group are inside the regions of:[6]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time research of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental section diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact that these factors with each other make up a dwelling program. The trick of said lifetime, I think, lies from the interactions, the interplay of All those molecules. The big concern concerning the origin of lifetime is still unanswered. How did we at any time evolve from very simple molecules to the extremely intricate systems we see currently? We don't know. I want to operate on these kinds of massive, open up concerns.’
Nanopores depict a sublime and versatile Instrument to evaluate single molecules. We study novel detection modes with strong-state nanopores and various strategies to measure proteins with nanopores. Tasks encompass the subsequent:
‘You should not just think of the issues of tomorrow, but will also evaluate the issues with the working day immediately after tomorrow’
Extremely cool, but that wasn’t genuinely exactly where my desire lay. I desired to pioneer And that i had the sensation that was not probable, because the most interesting fundamental insights had now been uncovered. But my discipline experienced created several thrilling new applications to measure personal molecules. I made a decision which i wanted to implement this to biology, to look at it from a Bodily viewpoint.’
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, to start with demonstration of molecular sorting inside a lab over a chip applying biomotors; discovery of nanobubbles in strong-condition nanopores; and initially estimate of electrokinetic energy conversion within a nanofluidic channel
Visualization ceesdekker of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy approaches
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments